blood-brain barrier

The Study of Lymphatic Draina ge Function of the Brain After Opening the Blood-Brain Barrier and During Drugged Sleep

In studies on male adult rats, the activation of the functions of the lymphatic system of the brain (LSM) was studied during drugged sleep and after the opening of the blood-brain barrier (BBB) by sound. The cleaning and drainage functions of LSM were studied by removing contrast agents from the brain in real time using magnetic resonance imaging (MRI) and optical coherence tomography (OCT).

Changes in the Permeability of the Blood-Brain Barrier in the Development of Alzheimer’s Disease in Mice

In our study on mice with an injection model of Alzheimer’s disease (AD), beta-amyloid detection in the brain tissue was evaluated using immunohistochemistry and confocal analysis. An accumulation of toxic protein was shown in different areas of the brain, predominantly in the cortex and in the hippocamp (place of beta-amyloid injection). Neurofunctional tests were conducted to confirm the development of AD.

Changes in Blood-Brain Barrier Permeability under the Influence of Loud Sound

The development of methods of drug delivery to the brain is one of the priorities of the therapy of most cerebral diseases. There are more than 70 technologies to overcome the blood-brain barrier (BBB), but many of them are not widely used in daily clinical practice, as they lead to negative consequences. Here we propose a new method of overcoming the BBB using loud sound (110 dB, 370 Hz, duration – 2 hours).

Optimization of Photodynamic Effects on Permeability of Cerebral Vessels

Photodynamic treatment (PDT) causes a significant increase in the permeability of the blood-brain barrier (BBB) in healthy mice. Using different doses of laser radiation (635 nm, 10–40 J/cm2 ) and photosensitizer (5-aminolevulinic acid – 5-ALA, i.v.), we found the optimal PDT for the reversible opening of the BBB, exhibiting brain tissue recovery 3 days after PDT. Further increases in the laser radiation or 5-ALA doses have no amplifying effect on the BBB permeability, but are associated with severe damage of brain tissues.