Izvestiya of Saratov University.

Chemistry. Biology. Ecology

ISSN 1816-9775 (Print)
ISSN 2541-8971 (Online)


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(downloads: 190)
Language: 
Russian
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Article type: 
Article
UDC: 
612.825

The Study of Lymphatic Draina ge Function of the Brain After Opening the Blood-Brain Barrier and During Drugged Sleep

Autors: 
Zinchenko Ekaterina M., Saratov State University
Klimova Maria M., Saratov State University
Khorovodov Aleksandr P., Saratov State University
Agranovich Ilana M., Saratov State University
Esma Sharif Ali, Saratov State University
Terskov Andrey V., Saratov State University
Dubrovsky Alexander I., Saratov State University
Shirokov Aleksandr A., Institute of Biochemistry and Physiology of Plants and Microorganisms of the Russian Academy of Sciences
Mamedova Aysel T., Saratov State University
Blohina Inna A., Saratov State University
Lezhnev Nikita D., Saratov State University
Romashchenko Alexander V., Institute of Cytology and Genetics SB RAS
Tuchin Valeriy V., Saratov State University
Semyachkina-Glushkovskaya Oksana V., Saratov State University
Abstract: 

In studies on male adult rats, the activation of the functions of the lymphatic system of the brain (LSM) was studied during drugged sleep and after the opening of the blood-brain barrier (BBB) by sound. The cleaning and drainage functions of LSM were studied by removing contrast agents from the brain in real time using magnetic resonance imaging (MRI) and optical coherence tomography (OCT). It was found that the opening of the BBB is accompanied by an immediate activation of the lymphatic drainage function of the brain, which is manifested in a faster elimination of gadolinium (MRI data) and gold nanorods (OCT results) from its tissues. For the first time, it was revealed that drug sleep and the opening of BBB have similar dynamics of changes in patterns reflected in the electrical activity of the brain. The results are pioneering and open up new physiological patterns in the study of the functions of LSM, which contribute to the appearance of innovative strategies in the development of breakthrough technologies in therapeutic modulations of the lymphatic drainage processes of the brain.

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Received: 
31.08.2020