1

This work demonstrates the possibility of obtaining new biologically active molecules containing a privileged imidazolone fragment by the Brønsted acid-catalyzed reaction of 1,3-dimethylurea with 1-(2-oxo-2-phenylethylidene)pyrrolo[3,2,1-ij]quinolin-2-ones. The presence of an active oxoylidene system in ones makes it possible to introduce these compounds into cyclization reactions with various binucleophilic agents.

Reactions of 4-oxobutanoic acids as well as their cyclic analogues 3H-furan-2-ones with 1,3-binucleophilic reagent (2-aminophenyl) methanol lead to the formation of 1-R-5H-benzo[d]pyrrolo[2,1-b][1,3]oxazines and 3a-R-2,3,3a-trihydro-5H-benzo[d]pyrrolo[2,1-b][1,3]oxazin1-ones, respectively. Quantum-chemical calculations of the Fukui reactivity indices and local hardness have substantiated the mechanisms of the reactions carried out.

Впервые выявлена интенсивно красная пигментация мицелия,
обусловленная накоплением элементного селена в резуль-
тате трансформации селенорганического соединения выс-
шим грибом Lentinula edodes (шиитаке). Исследовано влияние
1,5-дифенил-3-селенпентандиона-1,5 (диацетофенонилселенид,
препарат ДАФС-25) на рост съедобного гриба Lentinula edodes
в условиях жидкофазного и твердофазного культивирования.
Обнаруженное явление стимуляции роста мицелия предположи-
тельно связано с антиоксидантными свойствами селена, благо-

The reaction of 1,3-dipolar cycloaddition of conjugated aryl(hetaryl) methylideneacetones, which containing various peripheral substituents, with azomethine ylides was carried out. It was established that the interaction is not chemoselective and proceeds with the participation of two non-equivalent reaction centers of dipolarophile with high diastereoselectivity. The products of cycloaddition were a mixture of structural isomers endo-cycloaddition. Monoenone transform to spyropyrrolidines with high endo-stereoselectivity.

Aryl-substituted triazolohexahydroquinazolines have been synthesized by means of three-component condensation of pnitro(pbromo) benzaldehydes, cyclohexanone, 1,2,4-triazol-3-amine. A scheme of the reaction mechanism is proposed, which makes it possible to explain the features of the behavior of p-nitro(bromo) benzaldehydes in condensation reactions in comparison with their ortho-substituted analogs.

 A series of novel spirooxindoles have been synthesized through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and sarcosine with the dipolarophile 3-phenyl-1-(heteroaryl -2-yl)prop-2-en-1- one, synthesized by the Knoevenagel reaction using 2-acetylfuran, 2-acetylpyrrole, 2-acetylthiophene and substituted benzaldehydes. These compounds are used for the first time as dipolarophiles.