The combined effect of coatings based on nanoparticles of metals Ag, Au, ultraviolet (365 nm, UVR) and infrared (808 nm, IRR) radiation on Staphylococcus aureus 209 P was studied. Decrease in numbers was shown by 2% in the case of silver coatings and by 8% in the case of gold coatings after 1 h incubation. However, exposure of the IRR to bacterial suspensions caused the death of 43% of the population after 5 min, 86% of the population after 30 min.