The combined effect of coatings based on nanoparticles of metals Ag, Au, ultraviolet (365 nm, UVR) and infrared (808 nm, IRR) radiation on Staphylococcus aureus 209 P was studied. Decrease in numbers was shown by 2% in the case of silver coatings and by 8% in the case of gold coatings after 1 h incubation. However, exposure of the IRR to bacterial suspensions caused the death of 43% of the population after 5 min, 86% of the population after 30 min. The decrease in the number of the studied microorganisms was measured as 21% after 5 min and by 75% after 30 min of exposure to silver nanocoatings in combination with UVR (365 nm). The decrease in the number of bacterial cells on the surface of gold nanocoatings was 63% and occurred after 5 min and was 99% after 30 min of exposure to IRR (808 nm). The high antibacterial efficacy of a combination of gold nanocoatings and IRR can be explained by a higher density of radiation power, as well as a greater sensitivity of microorganisms to photothermal effects.