Izvestiya of Saratov University.

Chemistry. Biology. Ecology

ISSN 1816-9775 (Print)
ISSN 2541-8971 (Online)

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Photodynamic Diagnostics of Stomach Cancer

Agranovich Ilana M., Saratov State University
Khorovodov Aleksandr P., Saratov State University
Mamedova Aysel T., Saratov State University
Shnitenkova Anastasia A., Saratov State University
Shimanova Veronika E., Saratov State University
Novolokin Nikita A., Saratov State Medical University
Vashenko Tatiana S., Saratov State University
Kanevsky Matvey V., Saratov State University
Galitskaya Anna A., Saratov State University
Konnova Svetlana Anatolyevna, Saratov State University
Borisova Ekaterina G., Saratov State University
Semyachkina-Glushkovskaya Oksana V., Saratov State University

Cancer of the stomach is the main cause of death among cancer diseases of the gastrointestinal tract. This is due to the late diagnosis. This study was aimed at developing new methods for diagnosis of gastric cancer using a photosensitizer 5-ALK / PIXIX. The experiments were carried out on white non-native rats with an average mass of 250 grams. The animals were divided into 2 groups: control and experimental (stress + nitrosamine diet). The results of the studies, averaged for this type of tissue, clearly show significant differences between normal, precancerous and malignant changes in the stomach tissues of rats. The fluorescence from malignant neoplasms in the organ was maximal at 635 nm, where the protoporphyrin emission maximum is located due to the high accumulation of photosensitizer in the tissues. The most important result was the fact that precancerous changes (atrophic gastritis), which subsequently were confirmed histologically, were also detected in the process of photodiagnostics. The intensity of fluorescence in this case occupied an intermediate value between the norm and malignant lesions of the stomach.


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