Izvestiya of Saratov University.

Chemistry. Biology. Ecology

ISSN 1816-9775 (Print)
ISSN 2541-8971 (Online)


For citation:

Rogov D. A., Krivenko A. P. Cycvalone in the synthesis of nitrogen-, oxygen-containing heterocycles. Izvestiya of Saratov University. Chemistry. Biology. Ecology, 2023, vol. 23, iss. 2, pp. 159-165. DOI: 10.18500/1816-9775-2023-23-2-159-165, EDN: BUMKGQ

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Russian
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Article
UDC: 
547.875
EDN: 
BUMKGQ

Cycvalone in the synthesis of nitrogen-, oxygen-containing heterocycles

Autors: 
Rogov Danila A., Saratov State University
Krivenko Adel P., Saratov State University
Abstract: 

Cycvalone is an analogue of curcumin (EE conformation), exhibits a wide range of biological activity (antioxidant, hepatoprotective, membrane stabilizing, anti-ulcer) and is used in medical practice as a choleretic. Numerous methods of producing cycvalone are known, including industrial ones, but its reactions have been studied much less. Some reactions of cycvalone with N, C-nucleophiles (hydrazines, malononitrile) have been carried out. Reactions with getarylamines that could lead to the synthesis of compounds including pharmacophore fragments remained completely unexplored. We have used cycvalone as a substrate for the synthesis of nitrogen-, oxygen-containing heterosystems of a number of chromenopyrimidine, aminochromencarbonitrile, indazole, triazoloquinazoline. The structure of the obtained new substances has been established by spectral methods (IR, NMR). Schemes of formation of reaction products have been proposed.

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Received: 
22.02.2023
Accepted: 
07.03.2023
Published: 
30.06.2023
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