condensation

The relevance of research in the fi eld of chemistry of compounds of a number of 2-aminochromen(pyran)-3-carbonitrile is due to their practical signifi cance and numerous transformation possibilities. Over the past two decades, there has been a dynamic development of the electrochemical synthesis of compounds of this series, which is determined by the possibility of eliminating expensive or toxic reagents, conducting reactions at normal temperatures and pressure in electrolyzers of a fairly simple design and other advantages.

Cycvalone is an analogue of curcumin (EE conformation), exhibits a wide range of biological activity (antioxidant, hepatoprotective, membrane stabilizing, anti-ulcer) and is used in medical practice as a choleretic. Numerous methods of producing cycvalone are known, including industrial ones, but its reactions have been studied much less. Some reactions of cycvalone with N, C-nucleophiles (hydrazines, malononitrile) have been carried out.