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Тучина Е. С. Некоторые аспекты антимикробного фотодинамического воздействия // Известия Саратовского университета. Новая серия. Серия: Химия. Биология. Экология. 2022. Т. 22, вып. 1. С. 33-46. DOI: 10.18500/1816-9775-2022-22-1-33-46
Некоторые аспекты антимикробного фотодинамического воздействия
Антимикробная фототерапия является альтернативным методом борьбы с клинически значимыми микроорганизмами, ассоциированными с поражениями кожи, слизистых оболочек ротовой полости, дыхательного, желудочно-кишечного и урогенитального трактов. Метод использует нетоксичные красители, называемые фотосенсибилизаторами, молекулы которых могут возбуждаться безвредным видимым светом с образованием активных форм кислорода. Многочисленные исследования метода in vitro и in vivo продемонстрировали уничтожение микроорганизмов или существенное сокращение их численности. Активные формы кислорода продуцируются при фотоактивации и атакуют такие мишени, как белки, липиды и нуклеиновые кислоты, присутствующие внутри микробных клеток. Обзор суммирует современные данные по антимикробному фотовоздействию.
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