гетероциклизация

Inter- and intramolecular heterocyclisation carbonyl compounds and them thiacarbam derivatives an alicyclic structure depending of activation of nucleophilic centers it is carried out regiodirectly with formation of unknown earlier annelic and spitoycitic compounds thiazolic and thiadiazolic lines, perspective by way of studying biological activity.

Приведены данные по получению замещенных гексагидротетразолохиназолинов на основе
кросс-сопряженных диеноновых производных циклогексана и 5-амино-1,2,3,4-тетразола.
Обсуждены вопросы по регионаправленности реакций и строению полученных веществ.
 

Given the ability of 1,5-dicarbonyl compounds to emerge in the presence of ammonia, urea and its derivatives of N-containing heterocyclic compounds, possibility of сyclization 2-pentene- and pentane-1,5-diones and their dihalogensubstituted analogues with thioacetamide.

The possibility of obtaining asymmetric 1,5-diketones based on 4-hydroxy-2H-chromen-2-one and dimedone by three-component condensation in the presence of L-proline as a catalyst is shown. As a result, a series of 4-hydroxy3 - ((2-hydroxy-4,4-dimethyl-6-oxocyclohex1-en-1-yl) (aryl) methyl) -2H-chromen-2-ones was obtained with a yield of 25 up to 73%. The study revealed that the highest yield was observed for compounds containing fragments of ortho-substituted aldehydes capable of forming a hydrogen bond. For meta- and para-substituted – the lowest yield was observed.