Izvestiya of Saratov University.

Chemistry. Biology. Ecology

ISSN 1816-9775 (Print)
ISSN 2541-8971 (Online)

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Detection of Pharmaceuticals Using Magnetic Sers-active Core–Shell Structures

Markina Natalia Evgenievna, Saratov State University
Pozharov Michail Vladimirovich, Saratov State University
Zakharevich Andrey Machailovich, Saratov State University
Burmistrova Natalia Anatolievna, Saratov State University
Markin Aleksey Viktorovich, Saratov State University

The work is devoted synthesis, investigation and application of composites based on calcium carbonate microspheres, with embedded nanoparticles of magnetite (Fe3O4), coated by silver nanostructured shell. This composite (SERS-substrate) was used for surface-enhanced Raman spectra (SERS) registration of rhodamine 6G and different pharmaceuticals such as ipratropium bromide, chloramphenicol, propranolol, pindolol, tamoxifen, diltiazem. SERS analysis was performed via addition of analyzed solution to SERS-substrate, sorption step, separation of SERS-substrate with analyzed molecules from supernatant by magnet and, finally, SERS spectra registration. Enhancement factor for obtained SERS-substrate was found around 107 (for rhodamine 6G). Remote control of this SERS-substrate by magnetic fields and high Raman enhancement enable wide applications range for fast and sensitive analysis on place.


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