Izvestiya of Saratov University.

Chemistry. Biology. Ecology

ISSN 1816-9775 (Print)
ISSN 2541-8971 (Online)


Full text:
(downloads: 97)
Language: 
Russian
Heading: 
Article type: 
Article
UDC: 
544.522.121.2:546.661:615.33

Fluorimetric Determination of Pefloxacin in Pharmaceutical Preparation

Autors: 
Smirnova Tatiana D., Saratov State University
Zhelobitskaya Elena Alexandrovna, Saratov State University
Danilina Tatiana Grigorievna, Saratov State University
Abstract: 

It is shown that pefloxacin forms a terbium complexes in neutral and mildly acidic conditions which are characterized by energy transfer. It is found that the micellar surfactant medium energy transfer efficiency increases. The maximum increase sensitized fluorescence intensity is observed in the presence of SDS micelles. A fluorimetric method for determination of pefloxacin in the drug was developed.

Reference: 

1. Du L. M., Wang J. P., Wang C. X. The fl uorescence characteristics of micelle inclusion of pefl oxacin and its application // Guang Pu Xue Yu Guang Pu Fen Xi. 2004. Vol. 24, № 7. P. 855–857.

2. Veiopoulou C., Ioannou P., Lianidou E. Application of terbium sensitized fl uorescence for the determination of fl uoroquinolone antibiotics pefl oxa cin, ciprofl oxacin and norfl oxacin in serum // J. of Pharm. and Biomed. Analysis. 2003. Vol. 15, № 12. P. 1839–1844.

3. Shtykov S. N. Surfactants in analysis : Progress and development trends // J. of Analyt. Chem. 2000. Vol. 55, № 7. P. 608–614.