Izvestiya of Saratov University.

Chemistry. Biology. Ecology

ISSN 1816-9775 (Print)
ISSN 2541-8971 (Online)


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(downloads: 122)
Language: 
Russian
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Article type: 
Article
UDC: 
543:615.33

Express Method for Cefazolin Determination in Small Samples Sensors Planar Potentiometric

Autors: 
Kulapina Elena Grigorievna, Saratov State University
Chanina Viktoria V., Saratov State University
Abstract: 

The unmodified and modified by polyaniline and nanoparticles planar potentiometric sensors on the basis of tetradecylammonium associates with a complex silver (I) – cefazolin are created. Optimum ratios of components in carbon-containing ink are established: 30–32% carbon powder, 16–18% polyvinylchloride, 48–50% dibutylphthalate and 1–3% of electrode active compound (EAC). Planar sensors of two types are examined: electrode active compounds, electrode active compound and modifiers were added into in carbon-сontaining ink. Polyaniline (0.3–1.0%), nanoparticles of NiZnFeO and their binary mixtures were used as modifiers. Electroanalytical and operational characteristics of the unmodified and modified planar sensors in cefazolin solutions are estimated. NiZnFeO nanoparticles were the most effective modifier. It is shown that with the introduction of nanoparticles of NiZnFeO to carbon-containing ink leads to increase in the slopes of electrode functions (from 48±4 to 57±3), to a reduction of response time (from 20–25 till 5–10 sec), and to reduce potential drift (from 6–9 to 3–4 mV/day). At the same time intervals of linearity of electrode functions and limits of detection of cefazolin are identical for unmodified and modified (PANI, nanoparticles) sensors. Use of planar sensors for definition of cefazolin in model water solutions and oral fluid is shown.

Reference: 

1. Yakovlev V. P., Yakovlev S. V. Ratsional'naya antimikrobnaya farmakoterapiya [Rational antimicrobial pharmacotherapy]. Moscow, Litterra Publ., 2007. 784 p. (in Russian).

2. Honeychurch K. C., Hart J. P. Screen-printed electrochemical sensors for monitoring metal pollutants. Trends Anal. Chem., 2003, vol. 22, no. 7, pp. 456–469.

3. Gornall D. D., Collyer S. D., Higson S. P. J. Investigations into the use of screenprinted carbon electrodes as templates for electrochemical sensors and sonochemically fabricated microelectrode arrays. Sensor. Actuat. B–Chem., 2009, vol. 141, no. 2, pp. 581–591.

4. Wang J., Tian B., Nascimento V. B., Agnes L. Performance of screen-printed carbon electrodes fabricated from different carbon inks. Electrochim. Acta., 1998, vol. 43, no. 23, pp. 3459–3465.

5. Garcia-Gonzalez R., Fernandez-Abedul M. T., Pernia A., Costa-Garcia A. Electrochemical characterization of different screen-printed gold electrodes. Electrochim. Acta., 2008, vol. 53, no. 8, pp. 3242–3249.

6. Khaled E., Mohamed G. G., Awad T. Disposal screenprinted carbon paste electrodes for the potentiometric titration of surfactants. Sensor. Actuat. B–Chem., 2008, no. 135, pp. 74–80.

7. Markuzina N. N. Solid-contact lithium-selective electrochemical sensors based on conducting polymer poly(3-oktylthiophene). Successes of Modern Science, 2016, no. 2, pp. 39–43 (in Russian).

8. Milakin K. A., Menshikova I. P., Sergeev V. G. Polyaniline-polymer matrix composite material as a basis for creating a highly sensitive gas sensor for ammonia. Structure and Dynamics of Molecular System, 2008, no. 3, pp. 326–329 (in Russian).

9. Evtugyn G., Porfi reva A., Hianik T. Electropolymerized materials for biosensors. In: Advanced Bioelectronics Materials. Eds. A.Tiwari, H. K. Patra, A. P. F. Turner. Beverly, MA, Wiley-Scrivener Publ., 2015, pp. 89–184.

10. Kulapina E. G., Dubasova A. E., Kulapina O. I. Electroanalytical Properties of Non-modifi ed and Polyaniline Modifi ed Solid Contact Cefazolin Selective Sensors. Izv. Saratov. Univ. (N. S.), Ser. Chemistry. Biology. Ecology, 2018, vol. 18, iss. 1, pp. 13–19 (in Russian). DOI: https://doi.org/10.18500/1816-9775-2018-18-1-13-19

11. Makarova N. M., Kulapina E. G. Planar electrodes based on carbon nanotubes for the potentiometric determination of homologous sodium alkyl sulfates. Anal. Chem., 2015, vol. 70, no. 7, pp. 764–769 (in Russian).