Total Charge of Chitosan and Chitosan Succinyl Macromolecules Effect on the Stability of Particles of Silver Iodide Sols in Polymer-Colloidal Based Dispersions
Obtaining stable polymer-colloidal dispersions based on watersoluble polymers and inorganic colloidal particles, such as silver iodide sol, followed by removal of the dispersion medium is one of the ways to create hybrid biomedical materials (e.g. films, threedimensional matrices). The current work is devoted to studying the possibility of increasing the stability of polymer-colloidal systems based on silver iodide sols, succinyl chitosan and chitosan polysaccharides by reducing the total charge of macromolecules. It was shown that using particles of silver iodide sols as polymer stabilizers, partially neutralized chitosan and chitosan succinyl were observed to exhibit aggregative stability of the polymer-colloidal system. The absence of the increase in dispersions particles size for a rather long time was the evidence of that. It was found that decrease in the charge of chitosan macromolecules reduced the stability of polymer-colloidal dispersions based on chitosan and silver iodide sols with both positively and negatively charged particles. It was determined that for polymer-colloidal dispersions of succinyl chitosan-sol silver iodide in the case of a sol with negatively charged colloidal particles, the reduction in the charge of the macromolecule decreased the stability of the dispersion, while in the case of a sol with positively charged particles the stability is increased.
1. Fedotchev T. A., Olenin A. Yu., Starostin K. M., Lisichkin G. V., Banin V. V., Shimanovskii N. L. Prospects for the use of gold, silver and iron oxide nanoparticles to increase the effectiveness of chemotherapy for tumor neoplasms. Journal of Pharmacy and Chemistry, 2015, vol. 49, no. 4, pp. 11-22 (in Russian).
2. Eliopoulos P., Mourelatos D. Lack of genotoxicity of silver iodide in the SCE assay in vitro, in vivo, and in the Ames/microsome test. Teratogenesis, Carcinogenesis, and Mutagenesis, 1998, vol. 18, iss. 6, pp. 303–308.
3. Capelli Christofer C. Antimicrobial compositions useful for medical applications. Patent 5, 326,567 USA. 1994.
4. Shamratova V. G., Sharafutdinova L. A., Hismatullina Z. R., Bazunova M. V., Kulish E. I., Valiev D. R. Comparative evaluation of the effect of ultrafi ne systems based on complexes of chitosan and its derivatives with colloidal particles of silver iodide on the structural and functional properties of red blood cells. Biomedicine, 2015, no. 3, pp. 69 (in Russian).
5. Litmanovich O. E., Papisov I. M. Infl uence of the length of macromolecules on the particle size of a metal reduced in a polymer solution. Vysokomolekulyarnye soedineniya [High Molecular Weight Compounds]. A. 1999, vol. 41, no. 11, pp. 1824–1830 (in Russian).
6. Shchukin E. D., Percov A. V., Amelina E. A. Kolloidnaya himiya. 3-e izd., pererab. i dop. [Colloid Chemistry]. Moscow, Vysshaya shkola Publ., 2004. (in Russian).
7. Nepper D. Stabilizaciya kolloidnyh dispersij polimerami [Colloidal Dispersions’ Polymer Preservation]. Ed. by. Yu. S. Lipatova. Moscow, Mir Publ., 1986. 487 p. (in Russian).
8. Slivkin A. I., Lapenko V. L., Arzamascev A. P., Bolgov A. A. Aminoglucans as biologically active components of drugs (review for the period 2000–2004).Voronezh State University Journal. Seriya: Himiya. Biologiya. Farmaciya, 2005, no. 2, pp. 73–87 (in Russian).
9. Alekseeva T. P., Bogoslovskaya O. A., Olkhovskaya I. P., Glushchenko N. N., Rakhmetova A. A., Ilina A. V., Varlamov V. P., Baitukalov T. A., Levov A. N. Wound healing potential of chitosan and N-sulfosuccinoyl chitosan derivatives. Biology Bulletin, 2010, vol. 37, no. 4, pp. 339–345. DOI: https://doi.org/10.1134/S1062359010040023
10. Buzinova D. A., Abramov A. Yu., Shipovskaya A. B. Properties of chitosan fi lms of various chemical forms. Izv. Saratov Univ. (N. S.), Ser. Chemistry. Biology. Ecology, 2011, vol. 11, iss. 2, pp. 31–38 (in Russian).
11. Bazunova M. V., Valiev D. R., Yazlikbaeva D. Sh., Kulish E. I. The Method of Turbidity Spectrum in Determining the Size and Number of the Particles of Silver Iodide Sols.Bashkir University Journal, 2016, vol. 21, no. 1, pp. 53-54 (in Russian).
12. Klenin V. I. Termodinamika sistem s gibkocepnymi polimerami [Thermodynamics of Systems with Flexible Polymers]. Saratov, Izd-vo Saratovskogo universiteta, 1995. 736 p. (in Russian).
13. Klenin V. I., Shchegolev S. Yu., Lavrushin V. I. i dr. Harakteristicheskie funkcii svetorasseyaniya dispersnyh system [Characteristic Functions of Disperse Systems’ Light Diffusion]. Saratov, Izd-vo Saratovskogo universiteta, 1977. 177 p. (in Russian).
14. Schrand A. M., Ciftan Hens S. A., Shenderоva О. A. Nanоdiamоndparticles: Prоperties and Persprctives fоr biоapplicatiоns. Critical Reviews in Sоlid State Materials Sciences, 2009, vol. 34, pp. 18–74.
15. Lotov V. A. Nanodispersed Systems in Technology of Construction Materials and Produce. Tomsk Polytechnic University News, 2007, vol. 311, no. 3, pp. 84-88 (in Russian).