Izvestiya of Saratov University.

Chemistry. Biology. Ecology

ISSN 1816-9775 (Print)
ISSN 2541-8971 (Online)


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Russian
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Article type: 
Article
UDC: 
543.615.33

“Electronic tongue” multi-systems for the separate determination of cefotaxime and cefazoline

Autors: 
Kulapina Elena Grigorievna, Saratov State University
Dubasova Anastasia Е., Saratov State University
Kulapina Olga Ivanovna, Saratov State Medical University
Ankina Vlada D., Saratov State Medical University
Abstract: 

. Electroanalytical properties of unmodified and modified by polyaniline and by CuO nanoparticles solid-contact potentiometric sensors which are based on associates of tetradecylammonium with complex compounds of silver (I) with cephuroxime, cephotaxime and cephazoline Ag(?-lac)2TDA in solutions of corresponding antibiotics were studied. It was revealed that Ag(?-lac)2TDA –based sensors had no specificity to the basic ion but showed sensitivity to other cephalosporins. Taking into account the potentiometric selectivity coefficients and cross-sensitivity parameters of sensors based on different electrode-active components, their use for creating «electronic tongue» multi-sensor systems was shown. Arrays of low-selective potentiometric sensors were created for separate determination of cephazoline and cephotaxime in two-component model mixtures at concentration intervals of 2,5·10-4 – 0,01 М. The method of artificial neural networks was used for processing analytical signals (the relative error of determination not exceeding 13%). 

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Received: 
14.10.2020
Accepted: 
22.10.2020
Published: 
01.03.2021