oral fluid

Modified Potentiometric Sensors of Various Types for Ceftriaxone Determination

The planar unmodified and modified by polyaniline, nanoparticles and their binary mixtures potentiometric sensors of various types were manufactured on the basis of tetradecylammonium associates (TDA) with complex connections silver (I) – ceftriaxone (Ag (I) – Ceftr). In sensors of I type electroactive components (EAC) and modifiers were brought in carboniferous ink. The polyvinylchloride plasticized unmodified and modified membranes on the basis [Ag2 (Ceftr)2] 2- · 2TDA were used in the sensors of II type; C (EAC) = 1,2,3%.

The Research of the Behavior of Cefixime in Aquatic and Biological Media by Spectrophotometric Method

The research of behavior of cefixime in biological media was conducted by spectrophotometric method. It was shown that the maximum of light absorption of cefixime against the background of oral fluid is observed at λ = 292 nm and for blood serum at λ = 289 nm. The interval of linear dependence optical density – concentration of cefixime is 3–50 mkg/ml. The optimal conditions of precipitation of proteins in the studied biological media were revealed.

Solid-state Potentiometric Sensors for the Determination of Cefuroxime Axetil in Aqueous Media and Oral Fluid

Cefuroxime axetil is a cephalosporin antibiotic of the second generation, it is used in the sequential therapy of patient with sinusitis, community-acquired pneumonia, and other infectious somatic pathologies. For the determination of cephalosporin antibiotics in different objects, spectroscopic, chromatographic, electrochemical methods, immunoassay, etc. are used, which demand for expen- sive devices and organic solvents. Potentiometric sensors let one expressively detect cefalosporin antibiotics in small samples without previous sample preparation.