Synthesis and Heterocyclization of 4-Hydroxy-3 - ((2-hydroxy-4,4-dimethyl-6-oxocyclohex1-en-1-yl) (aryl) methyl) -2H-chromen-2-ones

The possibility of obtaining asymmetric 1,5-diketones based on 4-hydroxy-2H-chromen-2-one and dimedone by three-component condensation in the presence of L-proline as a catalyst is shown. As a result, a series of 4-hydroxy3 - ((2-hydroxy-4,4-dimethyl-6-oxocyclohex1-en-1-yl) (aryl) methyl) -2H-chromen-2-ones was obtained with a yield of 25 up to 73%. The study revealed that the highest yield was observed for compounds containing fragments of ortho-substituted aldehydes capable of forming a hydrogen bond. For meta- and para-substituted – the lowest yield was observed.

Some Transformation 2-Pentene-, Pentane-1,5-Diones and Their Halogen-Substituted Analogues with Thioacetamide

Given the ability of 1,5-dicarbonyl compounds to emerge in the presence of ammonia, urea and its derivatives of N-containing heterocyclic compounds, possibility of сyclization 2-pentene- and pentane-1,5-diones and their dihalogensubstituted analogues with thioacetamide.