aqueous media

Cefuroxime axetil is a cephalosporin antibiotic of the second generation, it is used in the sequential therapy of patient with sinusitis, community-acquired pneumonia, and other infectious somatic pathologies. For the determination of cephalosporin antibiotics in different objects, spectroscopic, chromatographic, electrochemical methods, immunoassay, etc. are used, which demand for expen- sive devices and organic solvents. Potentiometric sensors let one expressively detect cefalosporin antibiotics in small samples without previous sample preparation.

Cefazolin is a cephalosporin antibiotic of the third generation. It is widely used in medical practice for the therapy of various infectious-somatic pathologies. The work was aimed at the creation of solid-contact potentiometric cefazolin-selective sensors. For the first time, polyaniline was used to stabilize the potentials of solid-contact sensors. As the membranes active components, the compound of tetradecylammonium (TDA) with the silver (I) – cefazolin complex were applied.

The research of behavior of cefixime in biological media was conducted by spectrophotometric method. It was shown that the maximum of light absorption of cefixime against the background of oral fluid is observed at ? = 292 nm and for blood serum at ? = 289 nm. The interval of linear dependence optical density – concentration of cefixime is 3–50 mkg/ml. The optimal conditions of precipitation of proteins in the studied biological media were revealed.

The 1st generation cefalexine-cephalosporine antibiotic is used in the treatment of various infectious diseases. Spectrophotometry, kinetic spectrophotometry, spectrofluorimetry are proposed to determination of cefalexine in medicine and biological environment. Planar screenprinted sensors allow analyzing the micro-volumes of samples, which is important for the analysis of biological objects without preliminary samplepreparation. Depending on the active material and modifiers, you can create planar sensors for the determination of different organic compounds.