For citation:
Musaelyan A. G., Alipov V. V., Efimova E. S., Gritsai U. O., Sharabarina T. V., Tuchin V. V., Tuchina E. S. Photodynamic treatment using led red (660 nm) and laser infrared (808 nm) radiation for the treatment of simulated abdominal abscesses in laboratory animals. Izvestiya of Saratov University. Chemistry. Biology. Ecology, 2026, vol. 26, iss. 1, pp. 63-75. DOI: 10.18500/1816-9775-2026-26-1-63-75, EDN: MVUWJI
Photodynamic treatment using led red (660 nm) and laser infrared (808 nm) radiation for the treatment of simulated abdominal abscesses in laboratory animals
This study examined the eff ectiveness of antimicrobial photodynamic therapy (APDT) in the treatment of simulated purulent abdominal abscesses in laboratory animals. Two “radiation + photosensitizer” regimens were tested: 1) using red LED (660 nm) radiation and methylene blue, 2) using laser infrared (808 nm) radiation and indocyanine green. In vitro studies conducted in the fi rst phase determined the optimal APDT duration (at least 15 minutes) and the solvent type for each photosensitizer (0.24% Intralipid solution for methylene blue and 0.44% albumin solution for indocyanine green). It was found that 15-minute APDT sessions over 15 days resulted in the destruction of microorganisms in the abscess cavity, obliteration of the cavity, and normalization of physiological and biochemical blood parameters. To compare the two regimens, effi cacy coeffi cients were used. Analysis of these values revealed that laser infrared (808 nm) radiation combined with indocyanine green dissolved in 0.44% albumin produced a more pronounced therapeutic eff ect (on average, 5–6%). These results can be used to improve clinical practice in the treatment of bacterial intraperitoneal abscesses.
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