silver nanoparticles

Doxycycline is a broad-spectrum tetracycline antibiotic used to treat infections in humans and in veterinary medicine as a prophylactic drug and growth stimulant. For this reason, residual amounts of antibiotics in milk, meat and other food products can cause resistance and the development of allergies. In this regard, constant monitoring of residual contents of tetracyclines in food products, environmental objects, and biological fl uids is required.

The work is devoted synthesis, investigation and application of composites based on calcium carbonate microspheres, with embedded nanoparticles of magnetite (Fe3O4), coated by silver nanostructured shell. This composite (SERS-substrate) was used for surface-enhanced Raman spectra (SERS) registration of rhodamine 6G and different pharmaceuticals such as ipratropium bromide, chloramphenicol, propranolol, pindolol, tamoxifen, diltiazem.

The antimicrobial activity of the nanoparticles of silver stabilized by various natural and synthetic polymeric compounds concerning reference and clinical strains of Staphylococcus aureus is studied. It is established that the greatest effectiveness was displayed by the silver nanoparticles stabilized by polyvinyl alcohol, carboxymethylcellulose and poliazolidinammonium, the modified iodine hydrate ions. The low sensitivity of the studied strains to action of the nanoparticles stabilized by an oleate of S.