Цефотаксим

The method has been proposed for the spectrophotometric determination of antibiotics of the cephalosporin (cefuroxime, ceftriaxone, cefotaxime, cefazolin) and penicillin (amoxicillin) groups using chemometric data processing (method of partial least squares, PLS). The absorption spectra of 24 binary mixtures of “cephalosporin – cephalosporin” and 16 binary mixtures of “cephalosporin – amoxicillin” with various concentrations in the range of 3–27 and 5–140 μg/ml have been recorded.

An express authenticity estimation of some cephalosporin antibiotics of II and III generations are developed by spectrophotometry. An identity of drugs such as cefotaxime (Russia) and claforan (France), cefuroxime (Russia) and cefuroxime axetil (England) is shown.

Cefotaxime is a cefalosporin antibiotic possessing a high efficiency at curing severe bacterial infections. For the determination of cephalosporin antibiotics in different objects, spectroscopic, chromatographic, electrochemical methods, immunoassay, etc. are used, which demand for expensive devices and organic solvents. Potentiometric sensors let one expressively detect cefalosporin antibiotics in small samples without previous sample preparation.

Transport properties of the plasticized polyvinylchloride membranes on the basis of tetradecylammonium associates with complex connections silver (I) – cefotaxime in the conditions of a diffusive mass transfer and a direct current are investigated. With variation of concentration of electrode active substances (0.5; 1; 2; 3%), the external solutions contacting with membranes (10-2–10-7 M). It is established that resistance of membranes depends on the content of electrode active substances (EAS) and concentration of perimembrane solutions of a cefotaxime.

. Electroanalytical properties of unmodified and modified by polyaniline and by CuO nanoparticles solid-contact potentiometric sensors which are based on associates of tetradecylammonium with complex compounds of silver (I) with cephuroxime, cephotaxime and cephazoline Ag(?-lac)2TDA in solutions of corresponding antibiotics were studied. It was revealed that Ag(?-lac)2TDA –based sensors had no specificity to the basic ion but showed sensitivity to other cephalosporins.