Vibrio cholerae

Cultivation of production strains of Vibrio cholerae is one of the most important stages in the production of cholera bivalent chemical vaccines. In the production of immunobiological preparations, it is necessary to use producer strains with stable properties that persist in a number of generations. The aim of this study was to evaluate the expression of the ctxA gene using molecular genetic methods of the V. cholerae 569B producing strain.

Environmental pollution with industrial waste is an urgent problem today. A special place in the list of pollutants belongs to waste from biotechnological enterprises and industries, whose activities are related to the production of various drugs. Russian Research Anti-Plague Institute «Microbe» is the only manufacturer of unique immunobiological drugs in the Russian Federation – bivalent chemical cholera vaccine and rabies immunoglobulin from horse blood serum (AIG).