фотодинамическое воздействие

Antimicrobial phototherapy is an alternative method for combating clinically signifi cant microorganisms associated with lesions of the skin, mucous membranes of the oral cavity, respiratory, gastrointestinal and urogenital tracts. The method uses non-toxic dyes called photosensitizers, molecules that can be excited by harmless visible light to form reactive oxygen species.

Photodynamic treatment (PDT) causes a significant increase in the permeability of the blood-brain barrier (BBB) in healthy mice. Using different doses of laser radiation (635 nm, 10–40 J/cm2 ) and photosensitizer (5-aminolevulinic acid – 5-ALA, i.v.), we found the optimal PDT for the reversible opening of the BBB, exhibiting brain tissue recovery 3 days after PDT. Further increases in the laser radiation or 5-ALA doses have no amplifying effect on the BBB permeability, but are associated with severe damage of brain tissues.

Antimicrobial phototherapy is an alternative method for combating clinically signifi cant microorganisms associated with lesions of the skin, mucous membranes of the oral cavity, respiratory, gastrointestinal and urogenital tracts. The method uses non-toxic dyes called photosensitizers, molecules that can be excited by harmless visible light to form reactive oxygen species. Numerous studies of the method in vitro and in vivo have demonstrated the destruction of microorganisms or a signifi cant reduction in their number.