Study of Correlation between Growth Rate of Children and Monophtalate Concentrations in Urine
The study presents the results of determining of phthalate metabolites in urine of pre-school and primary school children by HPLC/MS. The correlation between growth rate of children and the concentration of phthalate metabolites in their urine was examined. The detected range of phthalate metabolite concentrations (mono-methyl phthalate, mono-butyl phthalate, mono-ethylhexyl phthalate) in urine of children was 0.0004–0.012 mg/dm3. The analysis of dependencies «urinary concentrations of phthalate metabolites and children growth rate» has revealed statistically significant inversely proportional dependence of the growth rate of the 7 years old boys on the urinary concentration of mono-methyl phthalate (R2=0.38; р<0.05).
1. Майстренко В. Н., Клюев Н. А.Эколого-аналитический мониторинг стойких органических загрязнителей. М., 2004. 323 с.
2. Toxicological Profi le for Di(2-ethylhexyl) Phthalate : U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry. N.Y., 1993. Р. 291.
3. Toxicological Profi le for DiethylPhthalate : U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry. N.Y., 1993. Р. 125.
4. Уланова Т. С., Карнажицкая Т. Д., Заверненкова Е. О. Оценка аэрогенного воздействияфталатов на легочную функцию детей дошкольного и младшего школьного возраста // Анализ риска здоровью. 2016. Вып. 1 (13). С. 50–56.
5. Blount B. C., Silva M. J., Caudill S. P., Needham L. L., Pirkle J. L., Sampson E. J., Lucier G. W., Jackson R. J., Brock J. W. Levels of seven urinary phthalate metabolites in a human reference population // Environ. Health Persp. 2000. Vol. 108. Р. 979–982.
6. Centers for Disease Control and Prevention, Department of Health And Human Services, USA. Second National Report on Human Exposure to Environmental Chemicals. National Center for Environmental Health, NCEH Pub. 2003. № 02-0716. URL: http://www.cdc.gov/ exposurereport/2nd/pdf/secondner.pdf
7. Frederiksen H., Aksglaede L., Sorensen K., Skakkebaek N., Juul A., Andersson A. Urinary excretion of phthalate metabolites in 129 healthy Danish children and adolescents: Estimation of daily phthalate intake // J. Environ. Res. 2011. Vol. 111. P. 656–663.
8. Guo Y., Wu Q., Kannan K. Phthalate metabolites in urine from China and implications for human exposures // J. Environ. Intern. 2011. P. 893–898.
9. Koch H., Rossbach B., Dexler H., Angerer J. Internal exposure of the general population to DEHP and other phthalates – determination of secondary and primary phthalate monoester metabolites in urine // Environ. Res. 2003. Vol. 93. Р. 117–185.
10. Kluwe W. Overview of Phthalate Ester Pharmacokinetics in Mammalian Species // Environ. Health Persp. 1982 . Vol. 45. Р. 3–10.
11. Deutsche Forschungsgemeinschaft. Di(2-ethylhexyl) phthalat (DEHP) // H. Greim (Hrsg.) : Gesundheitsschadliche Arbeitsstoffe – Toxikologisch-arbeitsmedizinische Begrundungen von MAK-Werten. Erganzungslieferung, Wiley-VCH, 2002. Vol. 35.
12. Tickner J., Schettler T., Guidotti T., McCally M., Rossi M. Health risks posed by use of di-2-ethylhexyl phthalate (DEHP) in PVC medical devices: A critical review // Amer. J. Ind. Med. 2001. Vol. 39. Р. 100–111.
13. Lowekamp-Swan T., Davis B. Mechanisms of Phthalate ester toxicity in the female reproductive system // Environ. Res. 2003. Vol. 111. P. 139–145.
14. Siddiqui A., Srivastava S. Effect of di(2-ethylhexyl) phthalate administration on rat sperm count and sperm metabolic enzymes // Bull. Environ. Contam. Toxicol. 1992. Vol. 48. P. 115–119.
15. Main K., Mortensen G., Kaleva M., Boisen K., Damgaard I., Chellakooty M., Schmidt I., Suomi A., Virtanen H., Petersen D., Andersson A., Toppari J., Skakkebaek N. Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in infants three months of age // Environ. Health Perspect. 2006. Vol. 114. Р. 270–276.
16. Miodovnik S., Canfi eld R. Prenatal phthalate exposure is associated with childhood behavior and executive functioning // Environ. Health Persp. 2010. Vol. 118. Р. 565–571.
17. Changming Xie, Yan Zhao, Lianlian Gao, Jiao Chen, Depei Cai, Yunhui Zhang. Elevated phthalates exposure in children with constitutional delay of growth and puberty // Molecular and Cellular Endocrinology. 2015. Vol. 407. P. 67–73.
18. Егорова А. И., Гачегов М. А., Аверьянова Н. И., Щер- бакова Л. И., Грузинцева О. Е. Оценка физического развития детей в практике участкового педиатра : учеб. пособие для студ. педиатр. фак., субординаторов и интернов, Пермь. 1994 . 35 с.
19. Гланц С. Медико-биологическая статистика: М. : Практика, 1999. 459 с.