Izvestiya of Saratov University.

Chemistry. Biology. Ecology

ISSN 1816-9775 (Print)
ISSN 2541-8971 (Online)

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Lymphatic Meningeal Role in Processes of Brain Clearing: in vivo Visualization

Duarte Torres Erik N., Saratov State University
Abdurashitov Arkadiy S., Saratov State University
Namykin Anton A., Saratov State University
Shirokov Aleksandr A., Institute of Biochemistry and Physiology of Plants and Microorganisms of the Russian Academy of Sciences
Shushunova Natalia A., Saratov State University
Sarantseva Elena I., Saratov State University
Semyachkina-Glushkovskaya Oksana V., Saratov State University

In the experiments on rats, Evans Blue dye and gold nanorods were injected into the brain parenchyma, followed by visualization with optical coherent tomography and a fluorescent microscopy. The results showed that meningeal lymphatics play an important role in the brain clearing, using markers introduced into the tissues. It has been shown that the deep cervical lymph node is the first anatomical “station” for the outflow of fluid from the brain. The data obtained shed light on the lymphatic mechanisms underlying the drainage and clearing of brain functions.


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