Izvestiya of Saratov University.

Chemistry. Biology. Ecology

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Destruction of the active substance of tetracycline under the action of UV irradiation

Ustinova Maria Nikolaevna, Federal State Autonomous Educational Institution of Higher Education
Zhunusov Nikita Sergeevich, Federal State Autonomous Educational Institution of Higher Education

The growth of the pharmaceutical industry inevitably leads to an increase in the concentration of organic pollutants in environmental objects. The problem of inactivation of such pollutants and water treatment is extremely urgent. The aim of this work was to use combined chemical methods of destruction of tetracycline, as one of the most commonly used antibiotics. The destruction of the active substance of tetracycline under UV irradiation, UV irradiation in the presence of hydrogen peroxide, and UV irradiation in the presence of hydrogen peroxide and ferrous iron ions was studied. It has been found that the active substance of tetracycline undergoes photodestruction at a fairly high rate, the degree of destruction reaches 75% within an hour. The kinetic characteristics of all three methods have been compared. It has been shown that the most intense oxidation of the active substance of tetracycline can be achieved by combined exposure to UV radiation and an oxidizer-hydrogen peroxide, after an hour the degree of destruction reaches 85.5%. However, the destruction of the active substance of the drug under UV irradiation in the presence of hydrogen peroxide and iron ions increases the initial speed of the process by 2–4 times, but reduces the efficiency to 66.7%. Photodestruction is quite effective, but not a universal method of inactivation of pollutants of pharmaceutical origin. In combination with oxidative degradation, it can be considered as a promising method for inactivating unusable drugs, as well as a method for local wastewater treatment in clinics and pharmaceutical industries.

  1. Barenbojm G. M. Zagryazneniye prirodnykh vod lekarstvami [Pollution of Natural Waters by Medicines]. Moscow, Nauka Publ., 2015, 283 p. (in Russian).
  2. Vodyanickij Yu. N., Yakovlev A. S. Contamination of soils and soil-ground waters with new organic micropollutants. Eurasian Soil Science, 2016, no. 5, pp. 609–619 (in Russian).
  3. Kozlova M. A. Pharmaceutical pollution of natural and waste waters: Methods of method and research results. The North Caucasus Ecological Herald, 2020, vol. 16, no. 1, pp. 77–80 (in Russian).
  4. Kujawa-Roeleveld K. Training material. Pharmaceutical compounds in environment. Removal of pharmaceuticals from concentrated wastewater streams in source oriented sanitation? Sustainable Water Management in the City of the Future, 2011. 69 p.
  5. Motuzova G. V., Karpova E. A. Khimicheskoye zagryazneniye biosfery i ego ekologicheskiye posledstviya [Chemical pollution of the biosphere and its environmental consequences]. Moscow, IMU Publ., 2013. 303 p. (in Russian).
  6. Samojlenko N. N., Ermakovich I. A. Contamination of municipal water pharmaceutical drugs and their derivatives. Eastern-European Journal of Enterprise Technologies, 2013, vol. 4, no. 10 (64), pp. 8–11 (in Russian).
  7. Daughton C. G. Pharmaceuticals in the Environment. J. Am. Soc. Mass. Spectrom, 2001, vol. 12, no. 10, pp. 1067–1076. https://doi.org/10.1016/S1044-0305(01)00287-2
  8. Richardson S. D., Ternes T. A. Water Analysis: Emerging Contaminants and Current Issues. Anal. Chem., 2018, vol. 90, no. 1, pp. 398–428. https://doi.org/10.1021/acs.analchem.7b04577
  9. Esipov S. E. Khimicheskaya entsiklopediya: Tetratsikliny: v 5 t. [Chemical Encyclopedia: Tetracyclines: in 5 vols.]. Moscow, Bol’shaya Rossiyskaya entsiklopediya Publ., 1995. 639 p. (in Russian).
  10. Neamtu M., Bobu M., Kettrup A., Siminiceanu I. Ozone photolysis of paracetamol in aqueous solution. J. Environ. Sci. Health. A, 2013, vol. 48, pp. 1264–1271.
  11. Moctezuma E., Leyva E., Aguilar C. A., Luna R. A., Montalvo C. Photocatalytic degradation of paracetamol: Intermediates and total reaction mechanism. J. Hazard. Mater., 2012, vol. 243, pp. 130–138.
  12. Andreozzi R., Caprio V., Marotta R., Vogna D. Paracetamol oxidation from aqueous solutions by means of ozonation and H 2O2/UV system. Water Res., 2003, vol. 37, pp. 993–1004.
  13. Huber M. M., Canonica S., Park G. Y., Gunten U. V. Oxidation of pharmaceuticals during ozonation and advanced oxidation processes. Environmental Science and Technology, 2003, vol. 37, no. 5, pp. 1016.
  14. Wols B. A., Hofman-Caris C. H. M. Review of photochemical reaction constants of organic micropollutants required for UV advanced oxidation processes in water. Water Res., 2012, vol. 46, pp. 2815–2827.
  15. Ustinova M. N., Lebedeva O. E. Oxidative Inactivation of Drugs. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 2014, no. 5 (5), pp. 1687–1690.
  16. Ustinova M. N., Lebedeva O. E. Inactivation of N-(4-hydroxyphenyl)acetamide peroxide oxidative systems. Belgorod State University Scientific Bulletin, 2014, vol. 27, no. 10 (181), pp. 117–120 (in Russian).
  17. Ustinova M. N., Lebedeva O. E., Kurdupova V. I. Photodestructive transformations of benzoic acid and its derivatives. Proceeding of Universities. Applied Chemistry and Biotechnology, 2017, vol. 7, no. 4, pp. 16–23 (in Russian).
  18. Ustinova M. N. Okislitel’naya destruktsiya kak sposob inaktivatsii ekopollyutantov farmatsevticheskogo proiskhozhdeniya [Oxidative degradation as a method of inactivating of pharmaceutical pollutants]. Thesis Diss. Cand. Sci. (Chem.). Belgorod, 2012. 20 p. (in Russian).
  19. Tyzhigirova V. V. Primeneniye ul’trafioletovoy, vidimoy i infrakrasnoy spektroskopii v analize lekarstvennykh sredstv [Application of ultraviolet, visible and infrared spectroscopy in the analysis of medicines]. Irkutsk, IGMU Publ., 2018. 72 p. (in Russian).
  20. Dolgoplosk B. A., Tinyakova E. I. Generirovaniye svobodnykh radikalov i ikh reaktsii [Generation of Free Radicals and Their Reactions]. Moscow, Nauka Publ., 1982. 254 p. (in Russian).
  21. Solozhenko E. G., Soboleva N. M., Goncharuk V. V. Application of the catalytic system H2O2-Fe2+(Fe3+) in water purification from organic compounds. Journal of Water Chemistry and Technology, 2004, vol. 26, no. 3, pp. 219–246 (in Russian).