Izvestiya of Saratov University.

Chemistry. Biology. Ecology

ISSN 1816-9775 (Print)
ISSN 2541-8971 (Online)

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Study of the diffusion process in films sodium salt of carboxymethyl cellulose – drug

Shurshina Anzhela S., Bashkir State University
Kulish Elena I., Bashkir State University

The transport properties of medicinal films based on sodium salt of carboxymethylcellulose and the antibiotic amikacin sulfate have been studied in this work. It has been shown that the process of sorption of water vapor by such films and the release of a drug from them proceeds in an abnormal diffusion mode, which is explained by the slowdown of relaxation processes in glassy polymers, which include the sodium salt of carboxymethylcellulose. An increase of the amount of the introduced drug is accompanied by a regular decrease in the diffusion coefficients of both the process of sorption of water vapor and the release of amikacin from the films. It is noted that the formed films of sodium salt of carboxymethylcellulose-amikacin sulfate dissolve in water during the day and do not provide a prolonged release of the drug. To reduce the solubility of the films in water, the surface modification of the polymer film with calcium chloride has been carried out. It has been found that the modification does not lead to a change in the diffusion mode, but is accompanied by a regular change in the diffusion coefficients – the longer the formed films were kept in a calcium chloride solution, the lower the diffusion coefficients of the sorption of water vapor by medicinal films and the diffusion coefficients of the release of the drug amikacin from the film. It is argued that the surface modification of polymer films based on the sodium salt of carboxymethylcellulose is an effective way of imparting to them the effect of prolonging the release of a drug.




  1. Mike Jenkins, ed. Biomedical Polymers. Cambridge, England, Woodhead Publishing Limited, 2007. 300 p. 
  2. Bajpai A. K., Shukla S. K., Bhanu S. Responsive Polymer in Controlled Drug Delivery. Progr. Polym. Sci., 2008, vol. 33, no. 1, pp. 1088–1118. https://doi.org/10.1016/j.progpolymsci.2008.07.005 
  3. Vilar G., Tulla-Puche J., Albericio F. Polymers and drug delivery systems. Current Drug Delivery, 2012, vol. 9, no. 4, pp. 367–394. https://doi.org/10.2174/156720112801323053 
  4. Uhrich K. E., Cannizzaro S. M., Langer R. S., Shakesheff K. M. Polymeric systems for controlled drug release. Chem. Rev., 1999, no. 10, pp. 3181–3198. https://doi.org/10.1021/cr940351u
  5. Shaik M.R., Korsapati M., Panati D. Polymers in Controlled Drug Delivery Systems. Int. J. Pharm. Sci., 2012, vol. 2, no. 4, pp. 112–116 
  6. Soppimath K. S., Aminabhavi T. M., Kulkarni A. R. Biodegradable polymeric nanoparticles as drug delivery devices. J. of Controlled Release, 2001, vol. 70, no. 1, pp. 1–20. https://doi.org/10.1016/S0168-3659(00)00339-4 
  7. Grigorieva M. V. Polymer systems with controlled release of biologically active compounds. Biotechnology, 2011, vol. 4, no. 2, pp. 9–23 (in Russian). 
  8. Gumargalieva K. Z., Zaikov T. E., Moiseev Yu. V. Macrokinetic aspects of biocompatibility and biodegradability of polymers. Russian Chemical Reviews, 1994, vol. 63, no. 10, pp. 905–921 (in Russian). https://doi.org/10.1070/ RC1994v063n10ABEH000122 
  9. Pkhakadze G. A. Morfologicheskie i biokhimicheskie aspekty biodegradatsii polimerov [Morphological and Biochemical Aspects of Polymer Biodegradation]. Kiev, Naukova Dumka Publ., 1986. 152 p. (in Russian). 
  10. Laschke M. W., Menger M. D. Prevascularization in tissue engineering: Current concepts and future directions. Biotechnology Advances, 2016, vol. 34, no. 2, pp. 112– 121. https://doi.org/10.1016/j.biotechadv.2015.12.004 
  11. Place E. S., Evans N. D., Stevens M. M. Complexity in biomaterials for tissue engineering. Nature Materials, 2009, vol. 8, no. 6, pp. 457–470. https://doi.org/10.1038/nmat2441 
  12. Johnson J. L., Jones M. B., Ryan S. O., Cobb B. A. The regulatory power of glycans and their binding partners in immunity. Trends in Immunology, 2013, vol. 34, no. 6, pp. 290–298. https://doi.org/10.1016/j.it.2013.01.006 
  13. Wang D. Glyco-epitope Diversity: An Evolving Area of Glycomics Research and Biomarker Discovery. Journal of Proteomics & Bioinformatics, 2014, vol. 7, no. 2. https://doi.org/10.4172/jpb.10000e24 
  14. Pradines B., Bories C., Vauthier C., Ponchel G., Loiseau P. M., Bouchemal K. Drug-Free Chitosan Coated Poly(isobutylcyanoacrylate) Nanoparticles Are Active Against Trichomonas vaginalis and Non-Toxic Towards Pig Vaginal Mucosa. Pharm Res., 2015, vol. 32, no. 4, pp. 1229–1236. https://doi.org/10.1007/s11095-014-1528-7 
  15. Dumitriu S. Polysaccharides. Structural Diversity and Functional Versatility. New York, Marcel Dekker, 2005. 1224 p. 
  16. Abou Taleb M. F., Alkahtani A., Mohamed S. K. Radiation synthesis and characterization of sodium alginate/ chitosan/hydroxyapatite nanocomposite hydrogels: a drug delivery system for liver cancer. Polym. Bull., 2015, vol. 72, no. 4, pp. 725–742. https://doi.org/10.1007/s00289-015-1301-z 
  17. Polimery meditsinskogo naznacheniya, pod red. S. Manabu [Manabu S., ed. Polymers for Medical Purposes]. Moscow, Meditsina Publ., 1981. 248 p. (in Russian). 
  18. Tkacheva N. I., Morozov S. V., Grigoriev I. A., Mognonov D. M., Kolchanov N. A. Modifi cation of cellulose is a promising direction in the creation of new materials. High-molecular Compounds, Series B, 2013, vol. 55, no. 8, pp. 1086–1107 (in Russian). https://doi.org/10.7868/ S0507547513070179
  19. Bondar V. A., Kazantsev V. V. The state of production of cellulose ethers. In: Bondar V. A., ed. Ethers of Cellulose and Starch: Synthesis, Properties, Application: materials of the 10th anniversary All-Russia scientifi c and technical. conf. from int. participation (May 5–8, 2003). Suzdal, 2003, pp. 9–26 (in Russian). 
  20. Kryazhev V. N., Shirokov V. A. The state of production of cellulose ethers. Chemistry of Vegetable Raw Materials, 2005, no. 3, pp. 7–12 (in Russian). 
  21. Berchenko G. N. Morphological Aspects of Complicated Wound Healing. Thesis Diss. Dr. Sci. (Med.). Moscow, 1997. 28 p. (in Russian). 
  22. Pat. 2352584 Rossiyskaya Federatsiya, MPK C08B 15/04 A61L 15/60. Sposob polucheniya gelya na osnove karboksimetiltsellyulozy [Method for Producing a Gel Based on Carboxymethyl Cellulose] (in Russian). 
  23. Verbitskiy D. A. The Use of Carboxymethyl Cellulose Gel for the Prevention of Adhesion in the Abdominal Cavity. Thesis Diss. Cand. Sci. (Med.). St. Petersburg, 2004. 19 p. (in Russian). 
  24. Wurster S. H., Bonet V., Mayberry A. Intraperitoneal sodium carboxymethylcellulose administration prevents reformation of peritoneal adhesions following surgical lysis. J. Surg. Res., 1995, vol. 59, no. 1, pp. 97–102. https://doi.org/10.1006/jsre.1995.1138 
  25. Treskova V. I., Shipina O. T., Romanova S. M. Interaction of sodium salt of carboxymethyl cellulose with allylamine. Bulletin of Technological University, 2016, vol. 19, no. 15, pp. 184–187 (in Russian). 
  26. Padokhin V. A., Ganiev R. F., Kochkina N. E. The effect of mechanical activation on the viscoelastic properties of solutions of mixtures of starch and sodium salt of carboxymethylcellulose. Doklady Akademii Nauk, 2007, vol. 416, no. 2, pp. 219–221 (in Russian).
  27. Danilova M. M., Peshekhonova A. L., Klimakova T. V., Golubev A. M., Rozantsev E. G. The infl uence of polysaccharide additives on the rheological characteristics of aqueous solutions of sodium salt of carboxymethyl cellulose. Izvestiya vuzov. Food Technology, 1994, no. 1-2, pp. 56–58 (in Russian). 
  28. Baranov V. G., Frenkel S. Ya., Agranova S. A., Brestkin Yu. V., Pinkevich V. N., Shabsels B. M. Concentration dependence of the viscosity of spiral polypeptide solutions. High-molecular Compounds, Series B, 1987, vol. 29, no. 10, pp. 745–747 (in Russian). 
  29. Arinshtein A. E. Effect of aggregation processes on the viscosity of suspensions. Sov. Phys. JETP, 1992, vol. 74, no. 4, pp. 646–650. 
  30. Crank J. The Mathematics of Diffusion. Oxford, Clarendon Press, 1975. 422 p. 
  31. Kulish E. I., Shurshina A. S., Kolesov S. V. Specifi c feature of water vapor sorption by chitosan medicated fi lms. Russian Journal of Applied Chemistry, 2013, vol. 86, no. 10, pp. 1537–1544. https://doi.org/10.1134/S107042721310011X 
  32. Kulish E. I., Shurshina A. S., Kolesov S. V. Transport properties of chitosan–amikacin fi lms. Russian Journal of Physical Chemistry B, 2014, vol. 8, no. 4, pp. 596–603. https://doi.org/10.1134/S1990793114040216 
  33. Hall P. J., Thomas K. M., Marsh H. The relation between coal macromolecular structure and solvent diffusion mechanisms. Fuel., 1992, vol. 71, no. 11, pp. 1271–1275. https://doi.org/10.1016/0016-2361(92)90053-Q