Izvestiya of Saratov University.
ISSN 1816-9775 (Print)
ISSN 2541-8971 (Online)

three-component synthesis

Investigation of the Structure and Ways of Formation of Isomeric Tyenylsubstituted Triazolohexohydroquinazolines by Methods of NMR Spectroscopy and Chromato-mass-spectromectry

In the three-component condensation of thiophenecarbaldehyde, cyclohexanone and 3-amino-1,2,4-triazole triazolohexahydroquinazolines are formed, which are isomeric in the type of the ring junction and the double bond position in them, the structure of which is established by 1H NMR spectra. With the GC-EIMS-analysis of the composition of the reaction mass at various temperatures, it has been established that an intermediate in the formation of final products is azomethine (instead of a possible ?,?-unsaturated ketone).