Izvestiya of Saratov University.
ISSN 1816-9775 (Print)
ISSN 2541-8971 (Online)


спектроскопия

Thionation of 4-((4-oxo-4H-chromen-3-yl)methylene)-2-phenyloxazol-5(4H)-one using the LAWESSON’S reagent

Analysis of periodicals has showed that there is no information on the behavior of hybrid heterocyclic systems containing several pharmacophore fragments based on oxazol-5(4H)-ones and chromen-4(4H)-ones in reactions with thionizing reagents under various conditions.

5-(1-Aryl-3-oxo-3-phenylpropyl)-2,2-dimethyl-1,3-dioxane-4,6-diones: synthesis and reactions with N-nucleophiles

2,2-Dimethyl-1,3-dioxane-4,6-dione (Meldrum acid, isopropylidenmalonate) is widely used by synthetic chemists due to its structural features. The dual nature of the reactivity of Meldrum acid (both electrophilic and/or nucleophilic reagent) determines the synthetic value in the construction of new heterocyclic systems with practically signifi cant properties. A wide range of biological activity has been revealed in a number of compounds containing a 2,2-dimethyl-1,3-dioxane-4,6-dione fragment in their structure.

4-Ethoxymethylene-2-phenyl-5(4H)-oxazolone in reactions with various heterocyclic amines

The analysis of the literature data has showed that there is no information on the behavior in 5(4H)-oxazolones with amines under the conditions of a sealed vessel reactor, which makes it possible to obtain heterocyclic systems with diff erent amines.