physicochemical methods

Analysis of periodicals has showed that there is no information on the behavior of hybrid heterocyclic systems containing several pharmacophore fragments based on oxazol-5(4H)-ones and chromen-4(4H)-ones in reactions with thionizing reagents under various conditions.

The analysis of the literature data has showed that there is no information on the behavior in 5(4H)-oxazolones with amines under the conditions of a sealed vessel reactor, which makes it possible to obtain heterocyclic systems with diff erent amines.

This work shows the possibility of synthesizing previously unknown 5-(4-bromophenyl)-3-((6-amino-2-mercaptopyrimidine)-4-amino)) methylidene-3H-furan-2-one containing a pharmacophore pyrimidine fragment by four-component one-pot reaction of malononitrile as the second methylene active component, thiourea, orthoester and 5-(4-bromophenyl)-3H-furan-2-one, which proceeds under mild conditions during thermal activation of the reaction mixture in isopropyl alcohol.

This work shows the possibility of synthesizing previously unknown 5-(4-bromophenyl)-3-((6-amino-2-mercaptopyrimidine)-4-amino)) methylidene-3H-furan-2-one containing a pharmacophore pyrimidine fragment by four-component one-pot reaction of malononitrile as the second methylene active component, thiourea, orthoester and 5-(4-bromophenyl)-3H-furan-2-one, which proceeds under mild conditions during thermal activation of the reaction mixture in isopropyl alcohol.