Izvestiya of Saratov University.
ISSN 1816-9775 (Print)
ISSN 2541-8971 (Online)

immunohistochemical and confocal analysis

Changes in the Permeability of the Blood-Brain Barrier in the Development of Alzheimer’s Disease in Mice

In our study on mice with an injection model of Alzheimer’s disease (AD), beta-amyloid detection in the brain tissue was evaluated using immunohistochemistry and confocal analysis. An accumulation of toxic protein was shown in different areas of the brain, predominantly in the cortex and in the hippocamp (place of beta-amyloid injection). Neurofunctional tests were conducted to confirm the development of AD.