Voronezh Oblast is traditionally important agricultural and plantgrowing region. The purpose of this study was to examine heavy metal contamination of medicinal plant products of Voronezh Oblast using the leaves of Plantago major L. that were collected in urban and agricultural ecosystems, exposed to anthropogenic impacts. The analysis was carried out using atomic absorption spectrometer MGA-915 MD, according to pharmacopeial methods. Accumulation of heavy metals (cadmium, chromium, cobalt, copper, lead, mercury, nickel, zinc) and arsenic in 51 samples of P.