Condensation of 2-aminobenzimidazole, ortho-substituted benzaldehydes and cyclohexanone proceeds with the formation of 10-o-Rsubstituted phenyl benz[4,5]imidazolo-6,7,8,9,10,11-hexahydro[1,2-a] quinazolines having angular articulation rings, strukture which is set using IR, NMR, 1 H, 13C spectra.
To synthesize new potentially biologically active benzimidazoloquinazolines, a three-component condensation of 2-aminobenzimidazole, cyclohexanone and hydroxylatedbenzaldehydes was studied. The reaction proceeds regioselectively when the equimolar ratios of the reagents are boiled for 3 hours in N,N-dimethylformamide and is accompanied by the formation of ortho-phenyl substituted hexahydrobenz[4,5]imidazolo [1,2-a]quinazolines having an angular articulation of the rings and a different number and position of hydroxyl groups in the phenyl substituent.
