One of the promising directions of carbon-neutral energy development is the development of technologies for biofuel production from microalgae. Eff ective control of biotechnological processes in the fi eld of cultivation of such microalgae requires express and eff ective methods of process control. In this study, a fl ow-through photometric cell has been designed and fabricated for online determination of the biomass content of the microalgae Nannochloropsis sp. in the culture medium. The microalgae biomass has been cultured in a custom-made photobioreactor.