Environmental pollution from human activities is currently a serious environmental problem. Organic xenobiotics are slowly biodegraded and accumulate in the environment: regular monitoring not only confi rms the presence of various pollutants in rivers, soils, and the atmosphere, but also indicates their growth. Despite the fact that many methods have been proposed for the inactivation of chemical reagents and the removal of pollutants, there is still no universal method that can be applied to various classes of xenobiotics and used to create local, highly effi cient wastewater treatment facilities. The purpose of this work was to study the destructive processes of model systems of xenobiotics of various types and their mixtures. UV irradiation was used as a method of destruction. The work has studied the destruction of model substances: two dyes, three pharmaceuticals, and three nitro derivatives of phenol. The destructive processes of model systems of various pollutants have been studied. It has been shown that the studied substrates undergo photodestruction within the fi rst hour. The kinetic characteristics of these processes have been calculated. The mutual infl uence of substrates on the destruction process has been studied. The eff ect of pH on the degradation process has been shown. The results obtained indicate that UV irradiation can be considered as a promising method for inactivating various pollutants and their mixtures.