доксициклин

Environmental pollution is one of the most pressing problems facing humanity. The constant search for its solution is an important aspect of modern chemistry. The work studied the oxidative degradation of two antibiotics of the same pharmaceutical group, with a similar structure but diff erent properties.

Doxycycline is a broad-spectrum tetracycline antibiotic used to treat infections in humans and in veterinary medicine as a prophylactic drug and growth stimulant. For this reason, residual amounts of antibiotics in milk, meat and other food products can cause resistance and the development of allergies. In this regard, constant monitoring of residual contents of tetracyclines in food products, environmental objects, and biological fl uids is required.

Doxycycline has a wide range of antimicrobial and anti-infl ammatory properties and is used to treat various infectious diseases. Spectroscopic, chromatographic, electrochemical, immunoassay and other methods are used to determine tetracycline antibiotics in various objects. Planar sensors allow express detection of antibiotics in small sample volumes. Planar potentiometric sensors based on ion associations doxycycline – tetraphenylborate (Copt = 2–3%), modifi er – polyaniline, for the quantitative determination of doxycycline have been developed.

Fluorescence spectroscopy is a routine tool for studying cellular and molecular visualization, flow cytometry, medical diagnosis, forensic medical examination, genetic analysis, and also an analytical method. However, most available organic dyes used to produce an optical signal have a number of important limitations, such as hydrophobicity, low quantum yield, and low photostability.