Pyrazoles containing amino and carbonitrile groups have a wide range of biological activities, including antimicrobial, antiinflammatory, antitumor, antioxidant, and are used to create pesticides and dyes. Also, these compounds are synthons for the preparation of various polyheterocyclic compounds. New potentially biologically active 5-amino-3-aryl-1H-pyrazole-4-carbonitriles containing pharmacophoric substituents have been obtained via three-component condensation reactions of malonic dinitrile with substituted aromatic aldehydes and benzhydrazides or hydrazines.
Condensation of 2-aminobenzimidazole, ortho-substituted benzaldehydes and cyclohexanone proceeds with the formation of 10-o-Rsubstituted phenyl benz[4,5]imidazolo-6,7,8,9,10,11-hexahydro[1,2-a] quinazolines having angular articulation rings, strukture which is set using IR, NMR, 1 H, 13C spectra.
To synthesize new potentially biologically active benzimidazoloquinazolines, a three-component condensation of 2-aminobenzimidazole, cyclohexanone and hydroxylatedbenzaldehydes was studied. The reaction proceeds regioselectively when the equimolar ratios of the reagents are boiled for 3 hours in N,N-dimethylformamide and is accompanied by the formation of ortho-phenyl substituted hexahydrobenz[4,5]imidazolo [1,2-a]quinazolines having an angular articulation of the rings and a different number and position of hydroxyl groups in the phenyl substituent.
