The application of the Vierordt’s and the first derivative at the “zero crossing” methods was evaluated for the simultaneous determination of synthetic food dyes Yellow “sunset” (E110) and Ponso 4R (E124) in model solutions. The concentrations interval of components is established at which the principle of optical densities additivity is observed. For the implementation of the Vierordt’s method, wavelengths with the maximum difference in the absorption coefficients of the individual components (470.2 and 536.7 nm) were chosen.