Colloidal quantum dots (QDs) of lead sulfide have been synthesized and investigated using octadecene and white spirit as a solvent for sulfur, varying the concentration of precursors and the temperature of the process. A method has been proposed for the synthesis of these QDs using anhydrous white spirit as a solvent at a temperature of 200° C, which made it possible to obtain polygonal nanoparticles with an average diameter of 2 to 3.2 nm with a minimum spread in size (± 10%).