индикаторные бумаги

Indicator papers based on immobilized copper (II) sulfate have been obtained for the determination of the β-lactam antibiotic ceftriaxone. The interaction of immobilized copper (II) sulfate with ceftriaxone has been assessed using diff use refl ectance spectroscopy. Methods have been developed for visual colorimetric and colorimetric determination of the antibiotic using a smartphone camera, Adobe Photoshop CS5® software, and a regression model built using the Python programming language. Color test scales for rapid assessment of ceftriaxone content have been obtained.

Amoxicillin is a semi-synthetic aminopenicillin ?-lactam series with a wide spectrum of antibacterial activity against many gram-positive and gram-negative microorganisms. It is included in the list of essential drugs. Test systems for the detection and identification of amoxicillin are missing. We have obtained indicator papers with immobilized ninhydrin and p-dimethylaminobenzaldehyde for the test determination of amoxicillin. The reaction conditions were selected, depending on the temperature and time.

Cefuroxime is a cephalosporin antibiotic with a wide spectrum of antibacterial activity for gram-positive and gram-negative microorganisms. It is in the list of vital and essential drugs for medical use. Currently, spectroscopic, chromatographic, electrochemical methods are used to determine cefuroxime. In current study we developed test agents in the form of indicator papers and powders with an immobilized Fehling reagent for the rapid determination of cefuroxime. Cellulose paper and silica gel were used as a solid matrix to create testing means.

Test means based on immobilized Fehling’s reagent for the determination of cephalexin have been obtained. Methods for visual and colorimetric assessment of antibiotic concentration using a smartphone camera have been developed. The optimal conditions for the indicator reaction have been selected with varying heating time and temperature. For a visual semi-quantitative assessment of the content of cephalexin, a color scale has been obtained.