фотодинамическая терапия

In this work, we studied the development of tolerance to low-intensity violet (405 nm, 80 mW/cm2 , 72 J/cm2 ) LED radiation in a clinical antibiotic-resistant strain of Staphylococcus aureus 2a. The change in numbers during 20 cycles of irradiation was studied, the reaction of bacterial cells to oxidative stress was studied – sensitivity to the presence of hydrogen peroxide in the environment and catalase activity.

The regularities of radiation-induced changes in the population quan­ tity of Staphylococcus aureus, Escherichia coli, Candida albicans in the presence of blue LED light and nanoparticles were studied. The effect of the blue radiation on the bacteria S. aureus was not dose­ dependent.

Antimicrobial phototherapy is an alternative method for combating clinically signifi cant microorganisms associated with lesions of the skin, mucous membranes of the oral cavity, respiratory, gastrointestinal and urogenital tracts. The method uses non-toxic dyes called photosensitizers, molecules that can be excited by harmless visible light to form reactive oxygen species.

Antimicrobial phototherapy is an alternative method for combating clinically signifi cant microorganisms associated with lesions of the skin, mucous membranes of the oral cavity, respiratory, gastrointestinal and urogenital tracts. The method uses non-toxic dyes called photosensitizers, molecules that can be excited by harmless visible light to form reactive oxygen species. Numerous studies of the method in vitro and in vivo have demonstrated the destruction of microorganisms or a signifi cant reduction in their number.