In this study, in experiments on 35 healthy male mice of the C57BL/6 line weighing 25±3 g, it was shown that loud sound/music for 2 hours causes a temporary increase in the permeability of the blood-brain barrier (BBB) in rodents. To investigate changes in the permeability of the blood-brain barrier, the molecular mechanisms responsible for its discovery were investigated using laser speckle-contrast imaging of regional cerebral blood fl ow (rCBF), immunohistochemical analysis and biochemical analysis of adrenaline in blood plasma.
