cytokines

The objective of our in vivo and in vitro studies was to examine the molecular and cellular mechanisms of the anti-inflammatory and wound-healing effects of chitosan barriers when used for guided tissue regeneration (GTR) in a rabbit model. An ELISA test of the rabbit blood serum conducted during the treatment of alveolar bone defects has confirmed the ability of chitosan to reduce inflammation fast by suppressing the TNF- cytokine production.

It is well known that lipopolysaccharides (LPSs) from outer membranes and capsular polysaccharides of Gram-negative bacteria activate in- nate immune system of humans and mammals and can produce septic shock clinical signs. A beneficial effect of LPSs consists in moderate stimulation of production of endogenous mediators by immune system cells, thus increasing the resistance of the organism to infections. In this respect the development of non-toxic derivatives of bacterial glycopolymers with improved immunostimulary properties becomes urgent.