Antibacterial activity of diacetophenonylselinide (a compound 1) and its nitroderivative (a compound 2) on ten clinical strains of Staphylococcus aureus is studied. Much higher antibacterial activity of the compound 2 which in concentration of 0,01 mg/ml at various time of influence causes destruction of 10,6-69,2 % of bacterial cells in comparison with the control is found out.