Izvestiya of Saratov University.
ISSN 1816-9775 (Print)
ISSN 2541-8971 (Online)


Possibility of Determination of Specific Activity of O-Ag in the Production of Cholera Chemical Vaccine by Dot-Analysis

Cholera remains a global threat to public health. Even sporadic cases of importation of the infection cause significant socio-economic damage. In connection with the current situation, the development and improvement of modern safe chemical vaccines against cholera caused by V. cholerae O1 and O139 serogroups plays an important role in reducing the incidence, which is an important and promising direction of scientific research. 

Effect of the O-Antigen Chemical Structure in Different Subspecies of Francisella Tularensis on Immunological Reactions

The greatest diagnostic significance for tularemia is played by antibodies against lipopolysaccharide (LPS). Previously, it has been shown that specific antibodies that appear in the blood serum of laboratory animals infected with virulent strains and people who have recovered from tularemia can bind both to LPS Francisella tularensis and to LPS Francisella novicida, while after the vaccination specific antibodies to LPS F. novicida are absent.