Hydrogenated derivatives of acridine exhibit various types of biological activity – their antibacterial, antitumor, antiviral, psychoactive properties are known. Using the example of heteroanalogs of tacrine, a known cholinesterase inhibitor, it is shown that the replacement of the benzene ring in polycyclic systems with a fi ve-membered heterocycle leads to a decrease in the toxicity of the drug, but does not change the basic physiological activity. Thus, the synthesis of heteroanalogs of known benzannelated systems is an urgent task.
