Urbanization and human stress lead to ecosystem transformation and accumulation of ecotoxicants, including heavy metals, in plants. Medicinal plants such as large burdock (Arctium lappa L.) and medicinal dandelion (Taraxacum offi cinale L.) are widely used in medicine, but can accumulate both essential and toxic elements. The purpose of the study was to conduct a comparative analysis of the macro- and microelement composition of the roots of large burdock and medicinal dandelion, growing in the natural ecotope of the Voronezh region.