Izvestiya of Saratov University.
ISSN 1816-9775 (Print)
ISSN 2541-8971 (Online)


chemical modification

Complexation of Polymyxin B1 Derivatives with Heparin

The method of coprecipitation from aqueous solutions at a neutral pH value was used to study the interaction of polymyxin B1 derivatives with sodium heparinate. They were compared with the initial unmodified antibiotic and with the initial antibiotic in a solution of the corresponding polymer, covalently unbound with it.