Techniques of determination of the main substances in capsules of cephalexin and tablets of cefuroxime axetil have been elaborated. For separation of ancillary compounds, the two modes have been approbated, i.e. filtration and centrifugation. The advantage of the second means has been shown.
An express authenticity estimation of some cephalosporin antibiotics of II and III generations are developed by spectrophotometry. An identity of drugs such as cefotaxime (Russia) and claforan (France), cefuroxime (Russia) and cefuroxime axetil (England) is shown.
Potentiometric screen-printed cefuroxime axetil sensors were developed. The optimum membraneand carbon ink compositions were determined. The main sensor electroanalytical and operational characteristics were evaluated. The sensors were used to determination of cefuroxime axetil in small sample volumes of model water solutions and mixed saliva (oral fluid). Upgrading sensor designs opens up new sensor application for pharmaceutical kinetic antibiotic studies on the mixed saliva analysis and correction treatment of various pathological processes.
