Izvestiya of Saratov University.
ISSN 1816-9775 (Print)
ISSN 2541-8971 (Online)


bone defect

In Vivo and in Vitro Studies of the Effect of Chitosan on the Bone Defect Repair Process

The objective of our in vivo and in vitro studies was to examine the molecular and cellular mechanisms of the anti-inflammatory and wound-healing effects of chitosan barriers when used for guided tissue regeneration (GTR) in a rabbit model. An ELISA test of the rabbit blood serum conducted during the treatment of alveolar bone defects has confirmed the ability of chitosan to reduce inflammation fast by suppressing the TNF- cytokine production.